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MS: Acute severe attack
bulletMethylprednisone (Solumedrol): 1 gram iv infusion per day x 3 to 5 days
bulletFollowed by oral Prednisone taper
bullet60 mg qd x 7 days, then 60 mg qod x 7 days, then 40 mg qod x 7 days, then 20 mg qod x 7 days, then stop
bullet? H2 blocker for ulcer prophylaxis
bulletMonitor blood glucose
bulletWatch for infection

 

Multiple Sclerosis Symptomatic Treatment
bulletSpasticity treatment
Fatigue & heat sensitivity
bulletAmantadine (Symmetrel): 100 mg bid
bulletPemoline (Cylert):
bulletChewable tab: 37.5 mg, Tab: 18.75, 37.5, 75 mg
bulletdose: 18.75 mg - 37.5 mg am
bulletuse for short term
Neurogenic bladder: uninhibited, small capacity
bulletPhysical measure
bulletvoid on schedule q3h
bulletIntermittent catherization
bulletPropantheline bromide (Pro-Banthine)
bullettab: 7.5, 15 mg
bullet15 mg qid, increase gradually
bulletanticholinergic side effects
bulletOxybutynin (Ditropan)
bullettab: 5 mg, syrup: 5 mg/5ml
bullet5 mg bid, max 5 mg qid
bulletanticholinergic side effects
bulletDetrol (Tolterodine)
bulletusual 2 mg bid
bulletless dry mouth, reduce dose to 1 mg bid if liver dysfunction or on macrolide antibiotics or antifungal agent
bulletTricyclics: see review of antidepressant

Multiple sclerosis info center
Multiple sclerosis overview

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